TaBlitz at the Center
Our services follow a single journey—from analytical methods and early material understanding through formulation, manufacturing scale-up, training, and tech transfer. CT scanning and root-cause work sharpen the picture when tablets misbehave; the TaBlitz Gold Standard closes the loop by locking the process in with our software tools and platform.
What We Offer
Each step below is a stage in the value chain, with the same detail we previously showed in separate cards—now organized as a clockwise path starting with analytical methods, through development and manufacturing, to CT and root cause, and back to a locked-in process with TaBlitz.
Analytical Method
We build the analytical backbone: methods that connect material properties to quality attributes and regulatory expectations—so every later decision rests on data you can defend.
Method development and refinement for powder, granule, and tablet CQAs.
Chromatography, spectroscopy, thermal analysis, and other techniques for identity, purity, impurities, and solid-form understanding where applicable.
Traceable data packages that tie characterization to specifications and scale-up.
Preformulation
Understanding materials early avoids surprises in development and manufacturing. We apply compression physics and pharmaceutical material science to characterize your API and excipients.
API and excipient characterization: particle size, true density, flow, compatibility.
Compression and compaction behavior aligned with USP <1062> and Pharmeuropa 5.44.
Support for excipient vendor selection and change; early de-risking for scale-up.
Pre Registration
Define optimum ranges of manufacturing parameters for lead batches before regulatory submission, so you have flexibility to address issues during commercial scale-up.
Design space exploration for key process parameters and formulation variables.
Data packages that support regulatory submissions and post-approval changes.
Clear linkage between lab-scale characterization and commercial manufacturing ranges.
Formulation Development
Science-based formulation design that decodes the interplay of materials and process parameters. We use USP <1062> and TaBlitz data to ensure product integrity and manufacturability.
Formulation screening and process selection (wet/dry granulation, direct compression).
Compressibility, compactibility, and tabletability with shaped tooling where relevant.
TaBlitz platform and AI to turn characterization data into design and process decisions.
Formulation Troubleshooting
Dedicated expertise and advanced instrumentation to solve capping, lamination, picking, sticking, and other tableting issues.
Root-cause analysis using compression science, ejection forces, and strain rate sensitivity.
Shaped tooling and cup design to match your commercial tablet and reduce defects.
Data-driven recommendations for formulation or process changes.
Pilot Manufacturing
Pilot-scale batches bridge development and GMP: enough material and realism to characterize the process without jumping straight to full commercial risk.
Pilot and engineering batches with process characterization.
Alignment between lab data, equipment train, and future commercial scale.
Support for tech transfer inputs and batch record structure.
Start-Up Manufacturing
Commercial batches of your formulation in our manufacturing suite until your own facility is ready—seamless handover with full process and data package.
cGMP-compliant execution with full documentation and batch record support.
Process characterization and validation support; technology transfer as needed.
Same technology and rigor from development through to commercial batches.
Scale-Up
Structured scale-up from lab through pilot to commercial: matching equipment effects, batch sizes, and controls so the product behaves as designed.
Process development and optimization across scales.
Scale-up assessment, press simulations, and tooling trials.
Validation and qualification support; troubleshooting during scale-up.
Training
Hands-on, practical and scientific training for your team—from tablet press and tooling to USP <1062> and formulation techniques.
Tablet press operation, tooling setup, and troubleshooting.
USP <1062> and formulation science; compressibility, compactibility, tabletability.
We participate in and support select external training events.
Tech Transfer
Moving the process to another site or partner requires more than paperwork. We package methods, ranges, and tacit know-how so receiving teams can run with confidence.
Technology transfer and process transfer support with clear documentation.
Alignment of equipment, SOPs, and critical process parameters.
Joint troubleshooting and on-floor support during transfer batches.
TaBlitz Gold Standard
Our software and platform turn what you learned into a locked-in process: models, specifications, batch intelligence, and traceability so the next site and the next year repeat success—not rediscover problems.
TaBlitz SaaS and AI-assisted formulation tied to your characterization data.
Documentation and digital continuity from development through manufacturing.
The loop closes: analytical rigor and on-floor insight feed a standard you can sustain.
CT
When the problem is inside the tablet, high-resolution CT scanning reveals structure density, cracks, and coating coverage that routine QC cannot see.
Non-destructive 3D insight into cores, coatings, and defects.
Complements compression science and stability data for a full picture.
Ideal when failures are intermittent or visually ambiguous.
Root Cause
We connect CT, compression data, materials science, and manufacturing history to isolate mechanisms—not labels—so you fix the right lever.
What would you do if your tablets started failing stability in just a few days—and no one could explain why? A team recently faced exactly that: tablets swelling, coatings failing, and every new batch raising more questions than answers. What looked like a hygroscopic formulation problem turned out to be something entirely different.
With the help of Natoli Scientific, high-resolution CT scanning revealed what traditional QC could not see—hidden microcracks, density variations, and non-uniform coating thickness—allowing moisture to penetrate the core. Once the underlying mechanisms were understood, the path forward became straightforward. The issue was not guesswork anymore; it was engineering.
Sometimes the fastest way to solve a tablet problem is simply to look deeper. Your tablet already knows the problem. We help you see it.
Specific Services
Powder & Tablet Characterization
Analytical tools & performance testing for development, scale-up & troubleshooting.
Particle & Powder Physical Properties
Particle size distribution – laser diffraction (Malvern Mastersizer 3000 with dry powder feeder) & sieve analysis
Bulk, tapped, and true density (helium pycnometer)
Powder flow & rheology (powder rheometer): cohesion index, internal angle of friction, punch sticking assessment
Angle of repose
Dynamic moisture sorption analysis (e.g. Q5000 SA)
Granule moisture: loss on drying
Thermal & Compositional Analysis
High-sensitivity DSC (e.g. Q2000)
High-sensitivity TGA (e.g. Q5000)
Powder X-ray diffractometer (PXRD)
PerkinElmer® ATR-FTIR
Karl Fischer titration
UV spectrophotometry (e.g. Shimadzu UV-1240)
Zetasizer Nano ZS (zeta potential, nano particle size)
Tablet & Compression Performance
Basic and advanced compression studies (USP <1062>)
Excipient vendor selection/change guidance
API/excipient characterization
Manufacturing predictions: formulation scale-up assessment, press simulations, tooling trials
Compression science: Heckel analysis, work descriptors, ejection forces, strain rate sensitivity
Formulation troubleshooting: capping, lamination
Finished Tablet, Surface & Stability
Tablet breaking force (hardness) tester
Tablet friability testing
Disintegration testing
Dissolution testing
ICH stability chambers (temperature & humidity controlled)
pH meter
Agilent HPLC (stability indicating / assay)
Full suite supporting API/excipient evaluation, formulation optimization, process scale-up, and quality/stability assessment.
Manufacturing Capabilities
Lab-scale, start-up & full industrial solid dose services.
Lab-Scale Manufacturing
Blending
Wet granulation (high shear, low shear, fluid bed)
Dry granulation
Milling
Tablet compression
Tablet coating
Development and feasibility batches
Formulation screening and process selection
Compaction Simulation
Encapsulation
Start-Up / Pilot Manufacturing
Blending
Wet granulation (high shear, low shear, fluid bed)
Dry granulation
Milling
Tablet compression
Tablet coating
Pilot and small-scale commercial batches
Process characterization and feasibility
Compaction Simulation
Encapsulation
Supporting & Scale-Up
Process development & optimization
Scale-up from lab to commercial
Batch sizes from development through commercial
Technology transfer & process transfer support
Process characterization & validation support
cGMP-compliant execution across all scales
Documentation & batch record support
Formulation and process troubleshooting
Compaction Simulation
Encapsulation
Full Industrial Manufacturing
Blending
Wet granulation
Dry granulation
Milling & size reduction
Tablet compression
Film coating & sugar coating
Packaging (as required)
Commercial-scale batch production
Validation and qualification support
End-to-end solid dose capabilities from formulation development through commercial manufacturing.